4YV0

Crystal structure of Trypanosoma cruzi spermidine synthase in complex with (2S)-N-methyl-N-phenyl-2,3-dihydro-1,4-benzodioxine- 2-carboxamid

Summary for 4YV0

Entry DOI	10.2210/pdb4yv0/pdb
Related	4YUV 4YUW 4YUX 4YUY 4YUZ 4YV1 4YV2
Descriptor	Spermidine synthase, putative, 5'-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5'-DEOXYADENOSINE, (2S)-N-methyl-N-phenyl-2,3-dihydro-1,4-benzodioxine-2-carboxamide, ... (4 entities in total)
Functional Keywords	methyltransferase, polyamine synthesis, transferase
Biological source	Trypanosoma cruzi (strain CL Brener)
Total number of polymer chains	4
Total formula weight	138379.26
Authors	Amano, Y.,Tateishi, Y. (deposition date: 2015-03-19, release date: 2015-09-16, Last modification date: 2023-11-08)
Primary citation	Amano, Y.,Namatame, I.,Tateishi, Y.,Honboh, K.,Tanabe, E.,Niimi, T.,Sakashita, H. Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase Acta Crystallogr.,Sect.D, 71:1879-1889, 2015 Cited by PubMed: 26327378 DOI: 10.1107/S1399004715013048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation