4YU9

Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase

Summary for 4YU9

• Entry DOI: 10.2210/pdb4yu9/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase, ZINC ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: alzheimer disease, drug target, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Secreted : Q16769
• Total number of polymer chains: 3
• Total formula weight: 113883.27

Authors

Di Pisa, F.,Pozzi, C.,Benvenuti, M.,Mangani, S. (deposition date: 2015-03-18, release date: 2015-08-05, Last modification date: 2015-08-19)

• Primary citation: DiPisa, F.,Pozzi, C.,Benvenuti, M.,Andreini, M.,Marconi, G.,Mangani, S.; The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.; Acta Crystallogr.,Sect.F, 71:986-992, 2015; PubMed: 26249687; DOI: 10.1107/S2053230X15010389

Experimental method

X-RAY DIFFRACTION (2.1 Å)