4YU9
Crystal Structure of double mutant Y115E Y117E human Glutaminyl Cyclase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Glutaminyl-peptide cyclotransferase | polymer | 329 | 37489.3 | 3 | UniProt (Q16769) Pfam (PF04389) In PDB | Homo sapiens (Human) | Glutaminyl cyclase,sQC,Glutaminyl-tRNA cyclotransferase,Glutamyl cyclase,EC |
| 2 | A, B, C | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | A, C | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 939 | Chemie (HOH) |
Sequence modifications
A, B, C: 33 - 361 (UniProt: Q16769)
| PDB | External Database | Details |
|---|---|---|
| Glu 115 | Tyr 115 | engineered mutation |
| Glu 117 | Tyr 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 112467.8 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 1415.4 | |
| All* | Total formula weight | 113883.3 |
