4YN0

Crystal structure of APP E2 domain in complex with DR6 CRD domain

Summary for 4YN0

• Entry DOI: 10.2210/pdb4yn0/pdb
• Descriptor: Tumor necrosis factor receptor superfamily member 21, Amyloid beta A4 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: alzheimer, neuron pruning, amyloid precursor protein, apoptosis-cell adhesion complex, apoptosis/cell adhesion
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48427.18

Authors

Xu, K.,Nikolov, D. (deposition date: 2015-03-08, release date: 2015-04-15, Last modification date: 2024-10-30)

Primary citation

Xu, K.,Olsen, O.,Tzvetkova-Robev, D.,Tessier-Lavigne, M.,Nikolov, D.B.
The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation.
Genes Dev., 29:785-790, 2015

PubMed Abstract: The amyloid precursor protein (APP) has garnered considerable attention due to its genetic links to Alzheimer's disease. Death receptor 6 (DR6) was recently shown to bind APP via the protein extracellular regions, stimulate axonal pruning, and inhibit synapse formation. Here, we report the crystal structure of the DR6 ectodomain in complex with the E2 domain of APP and show that it supports a model for APP-induced dimerization and activation of cell surface DR6.

PubMed: 25838500
DOI: 10.1101/gad.257675.114

Experimental method

X-RAY DIFFRACTION (2.2 Å)