4YN0
Crystal structure of APP E2 domain in complex with DR6 CRD domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tumor necrosis factor receptor superfamily member 21 | polymer | 190 | 20702.7 | 1 | UniProt (Q9EPU5) Pfam (PF00020) | Mus musculus (Mouse) | Death receptor 6 |
| 2 | B (B) | Amyloid beta A4 protein | polymer | 233 | 27257.8 | 1 | UniProt (P12023) Pfam (PF12925) | Mus musculus (Mouse) | ABPP,APP,Alzheimer disease amyloid A4 protein homolog,Amyloidogenic glycoprotein,AG |
| 3 | C, E (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 102 | Chemie (HOH) |
Sequence modifications
A: 42 - 220 (UniProt: Q9EPU5)
B: 295 - 517 (UniProt: P12023)
| PDB | External Database | Details |
|---|---|---|
| Gly 40 | - | expression tag |
| Ser 41 | - | expression tag |
| Ala 221 | - | expression tag |
| Ser 222 | - | expression tag |
| Gly 223 | - | expression tag |
| Arg 224 | - | expression tag |
| Gly 225 | - | expression tag |
| Leu 226 | - | expression tag |
| Val 227 | - | expression tag |
| Pro 228 | - | expression tag |
| Arg 229 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 293 | - | expression tag |
| Ser 294 | - | expression tag |
| Ser 518 | - | expression tag |
| Gly 519 | - | expression tag |
| Arg 520 | - | expression tag |
| Gly 521 | - | expression tag |
| Leu 522 | - | expression tag |
| Val 523 | - | expression tag |
| Pro 524 | - | expression tag |
| Arg 525 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47960.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 466.7 | |
| All* | Total formula weight | 48427.2 |
