4YN0

Crystal structure of APP E2 domain in complex with DR6 CRD domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Tumor necrosis factor receptor superfamily member 21	polymer	190	20702.7	1	UniProt (Q9EPU5) Pfam (PF00020) In PDB	Mus musculus (Mouse)	Death receptor 6
2	B	Amyloid beta A4 protein	polymer	233	27257.8	1	UniProt (P12023) Pfam (PF12925) In PDB	Mus musculus (Mouse)	ABPP,APP,Alzheimer disease amyloid A4 protein homolog,Amyloidogenic glycoprotein,AG
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5		water	water		18.0	102	Chemie (HOH)

Sequence modifications

A: 42 - 220 (UniProt: Q9EPU5)

PDB	External Database	Details
Gly 40	-	expression tag
Ser 41	-	expression tag
Ala 221	-	expression tag
Ser 222	-	expression tag
Gly 223	-	expression tag
Arg 224	-	expression tag
Gly 225	-	expression tag
Leu 226	-	expression tag
Val 227	-	expression tag
Pro 228	-	expression tag
Arg 229	-	expression tag

B: 295 - 517 (UniProt: P12023)

PDB	External Database	Details
Gly 293	-	expression tag
Ser 294	-	expression tag
Ser 518	-	expression tag
Gly 519	-	expression tag
Arg 520	-	expression tag
Gly 521	-	expression tag
Leu 522	-	expression tag
Val 523	-	expression tag
Pro 524	-	expression tag
Arg 525	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47960.5
Non-Polymers*	Number of molecules	3
	Total formula weight	466.7
All*	Total formula weight	48427.2

*Water molecules are not included.