4YN0

Crystal structure of APP E2 domain in complex with DR6 CRD domain

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00652
Number of Residues	43
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. Cpagt..Ftrhengier.ChdCsqpCpwpmierlp..CaaltdrECIC

Chain	Residue	Details
A	CYS91-CYS133

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	41
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	34
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"TNFR-Cys 4"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	63
Details	Region: {"description":"Heparin-binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	17
Details	Region: {"description":"Collagen-binding","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05067","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PDB","id":"4YN0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI11
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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