4Y6M

Structure of plasmepsin II from Plasmodium falciparum complexed with inhibitor PG418

Summary for 4Y6M

• Entry DOI: 10.2210/pdb4y6m/pdb
• Related: 4CKU
• Descriptor: Plasmepsin-2, ~{N}1-[(~{Z},3~{R})-4-[2-(3-methoxyphenyl)propan-2-ylamino]-3-oxidanyl-1-phenyl-but-1-en-2-yl]-5-piperidin-1-yl-~{N}3,~{N}3-dipropyl-benzene-1,3-dicarboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: plasmepsin ii hydroxyethylamine-basd inhibitor, hydrolase
• Biological source: Plasmodium falciparum
• Cellular location: Vacuole: P46925
• Total number of polymer chains: 3
• Total formula weight: 113336.33

Authors

Recacha, R.,Akopjana, I.,Tars, K.,Jaudzems, K. (deposition date: 2015-02-13, release date: 2015-12-09, Last modification date: 2024-01-10)

• Primary citation: Recacha, R.,Leitans, J.,Akopjana, I.,Aprupe, L.,Trapencieris, P.,Jaudzems, K.,Jirgensons, A.,Tars, K.; Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors.; Acta Crystallogr.,Sect.F, 71:1531-1539, 2015; PubMed: 26625296; DOI: 10.1107/S2053230X15022049

Experimental method

X-RAY DIFFRACTION (2.27 Å)