Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | binding site for residue 48Q A 501 |
| Chain | Residue |
| A | ILE32 |
| A | TYR192 |
| A | ASP214 |
| A | GLY216 |
| A | THR217 |
| A | SER218 |
| A | THR221 |
| A | ILE290 |
| A | LEU292 |
| A | ILE300 |
| A | HOH656 |
| A | ASP34 |
| A | HOH675 |
| C | ASP279 |
| C | GLY281 |
| A | GLY36 |
| A | SER37 |
| A | VAL78 |
| A | PHE111 |
| A | THR114 |
| A | SER118 |
| A | ILE123 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 502 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | ASN95 |
| A | LEU96 |
| A | SER97 |
| A | HOH644 |
| A | HOH695 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue 48Q B 501 |
| Chain | Residue |
| A | GLY281 |
| A | PRO282 |
| B | ILE32 |
| B | ASP34 |
| B | GLY36 |
| B | VAL78 |
| B | SER79 |
| B | PHE111 |
| B | ILE123 |
| B | ASP214 |
| B | GLY216 |
| B | THR217 |
| B | SER218 |
| B | LEU292 |
| B | ILE300 |
| C | VAL78 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | TYR192 |
| B | ILE212 |
| B | PHE294 |
| B | VAL296 |
| B | THR298 |
| B | HOH650 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue 48Q C 501 |
| Chain | Residue |
| B | PRO295 |
| C | MET15 |
| C | ILE32 |
| C | ASP34 |
| C | GLY36 |
| C | SER37 |
| C | THR114 |
| C | TYR192 |
| C | ASP214 |
| C | GLY216 |
| C | THR217 |
| C | SER218 |
| C | ILE300 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 502 |
| Chain | Residue |
| A | VAL239 |
| A | GOL502 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | PRO243 |
| C | TYR245 |
| C | ILE289 |
| C | GLY291 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. FILDTGSANLWV |
| Chain | Residue | Details |
| A | PHE31-VAL42 | |
| A | CYS211-VAL222 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 921 |
| Details | Domain: {"description":"Peptidase A1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01103","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
