4Y6G
Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site.
Summary for 4Y6G
Entry DOI | 10.2210/pdb4y6g/pdb |
Related | 2CLE 2CLF 2WX2 4KKX 4XUG |
Descriptor | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total) |
Functional Keywords | lyase, tryptophan biosynthesis, salmonella typhimurium, f6f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Salmonella enterica subsp. enterica serovar Typhimurium More |
Total number of polymer chains | 2 |
Total formula weight | 72546.14 |
Authors | Hilario, E.,Caulkins, B.G.,Young, R.P.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2015-02-13, release date: 2016-02-10, Last modification date: 2023-09-27) |
Primary citation | Hilario, E.,Caulkins, B.G.,Huang, Y.M.,You, W.,Chang, C.E.,Mueller, L.J.,Dunn, M.F.,Fan, L. Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water. Biochim.Biophys.Acta, 1864:268-279, 2016 Cited by PubMed: 26708480DOI: 10.1016/j.bbapap.2015.12.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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