Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with N-(4'-trifluoromethoxybenzoyl)-2-amino-1-ethylphosphate (F6F) inhibitor in the alpha-site and beta-site.

Summary for 4Y6G

Related2WX2 2CLF 4KKX 2CLE 4XUG
DescriptorTryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-{[4-(TRIFLUOROMETHOXY)BENZOYL]AMINO}ETHYL DIHYDROGEN PHOSPHATE, ... (6 entities in total)
Functional Keywordslyase, tryptophan biosynthesis, salmonella typhimurium, f6f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological sourceSalmonella enterica subsp. enterica serovar Typhimurium
Total number of polymer chains2
Total molecular weight72546.14
Hilario, E.,Caulkins, B.G.,Young, R.P.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2015-02-13, release date: 2016-02-10, Last modification date: 2019-12-25)
Primary citation
Hilario, E.,Caulkins, B.G.,Huang, Y.M.,You, W.,Chang, C.E.,Mueller, L.J.,Dunn, M.F.,Fan, L.
Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water.
Biochim.Biophys.Acta, 1864:268-279, 2016
PubMed: 26708480 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbapap.2015.12.006
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.18630.2%0.6%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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