2WX2

X-RAY STRUCTURE OF CYP51 FROM THE HUMAN PATHOGEN TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE

Summary for 2WX2

Related2WV2 2WUZ
DescriptorLANOSTEROL 14-ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
Functional Keywordsp450, heme, iron, metal-binding, methyltransferase, ergosterol biosynthesis, oxidoreductase
Biological sourceTRYPANOSOMA CRUZI
Total number of polymer chains2
Total molecular weight110087.05
Authors
Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-31, release date: 2009-11-10, Last modification date: 2012-04-11)
Primary citation
Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M.
Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole
Plos Negl Trop Dis, 4:E651-, 2010
PubMed: 20386598 (PDB entries with the same primary citation)
DOI: 10.1371/JOURNAL.PNTD.0000651
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.27 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.267120.7%7.3%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution