2WX2

X-RAY STRUCTURE OF CYP51 FROM THE HUMAN PATHOGEN TRYPANOSOMA CRUZI IN COMPLEX WITH FLUCONAZOLE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	LANOSTEROL 14-ALPHA-DEMETHYLASE	polymer	473	54120.8	2	UniProt (Q7Z1V1) Pfam (PF00067)	TRYPANOSOMA CRUZI	CYP51
2	C, E (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D, F (A, B)	2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL	non-polymer		306.3	2	Chemie (TPF)
4	G, H (A, B)	water	water		18.0	429	Chemie (HOH)

Sequence modifications

A, B: 15 - 21 (PDB: 2WX2)
A, B: 482 - 487 (PDB: 2WX2)
A, B: 22 - 481 (UniProt: Q7Z1V1)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108241.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1845.5
All*	Total formula weight	110087.0

*Water molecules are not included.