4XUG

Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.

Summary for 4XUG

• Entry DOI: 10.2210/pdb4xug/pdb
• Related: 2CLI 2CLL 3PR2 4HN4 4HPJ 4HPX 4HT3
• Descriptor: Tryptophan synthase alpha chain, Tryptophan synthase beta chain, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... (7 entities in total)
• Functional Keywords: carbon-oxygen lyase, hydro-lyase, tryptophan biosynthesis, salmonella typhimurium, f9f, inhibitor, allosteric enzyme, aromatic amino acid biosynthesis, pyridoxal phosphate, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium; More
• Total number of polymer chains: 2
• Total formula weight: 72310.14

Authors

Hilario, E.,Caulkins, B.G.,Young, R.P.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L. (deposition date: 2015-01-25, release date: 2016-01-27, Last modification date: 2023-09-27)

• Primary citation: Hilario, E.,Caulkins, B.G.,Young, R.P.,Niks, D.,Dunn, M.F.,Mueller, L.J.,Fan, L.; Crystal structure of Tryptophan Synthase from Salmonella typhimurium in complex with 2-({[4-(Trifluoromethoxy)Phenyl]Sulfonyl}Amino)Ethyl Dihydrogen Phosphate (F9F) inhibitor in the alpha site and ammonium ion in the metal coordination site.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.65 Å)