4Y30

Crystal structure of human protein arginine methyltransferase PRMT6 bound to SAH and EPZ020411

4Y30 の概要

• エントリーDOI: 10.2210/pdb4y30/pdb
• 関連するPDBエントリー: 4Y2H
• 分子名称: Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, N,N'-dimethyl-N-({3-[4-({trans-3-[2-(tetrahydro-2H-pyran-4-yl)ethoxy]cyclobutyl}oxy)phenyl]-1H-pyrazol-4-yl}methyl)ethane-1,2-diamine, ... (6 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : Q96LA8
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81004.27

構造登録者

Swinger, K.K.,Boriack-Sjodin, P.A. (登録日: 2015-02-10, 公開日: 2015-04-22, 最終更新日: 2024-02-28)

主引用文献

Mitchell, L.H.,Drew, A.E.,Ribich, S.A.,Rioux, N.,Swinger, K.K.,Jacques, S.L.,Lingaraj, T.,Boriack-Sjodin, P.A.,Waters, N.J.,Wigle, T.J.,Moradei, O.,Jin, L.,Riera, T.,Porter-Scott, M.,Moyer, M.P.,Smith, J.J.,Chesworth, R.,Copeland, R.A.
Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
Acs Med.Chem.Lett., 6:655-659, 2015

PubMed Abstract: A novel aryl pyrazole series of arginine methyltransferase inhibitors has been identified. Synthesis of analogues within this series yielded the first potent, selective, small molecule PRMT6 inhibitor tool compound, EPZ020411. PRMT6 overexpression has been reported in several cancer types suggesting that inhibition of PRMT6 activity may have therapeutic utility. Identification of EPZ020411 provides the field with the first small molecule tool compound for target validation studies. EPZ020411 shows good bioavailability following subcutaneous dosing in rats making it a suitable tool for in vivo studies.

PubMed: 26101569
DOI: 10.1021/acsmedchemlett.5b00071

実験手法

X-RAY DIFFRACTION (2.1 Å)