4XWK

P-glycoprotein co-crystallized with BDE-100

Summary for 4XWK

• Entry DOI: 10.2210/pdb4xwk/pdb
• Descriptor: Multidrug resistance protein 1A, 2,4-dibromophenyl 2,4,6-tribromophenyl ether (2 entities in total)
• Functional Keywords: membrane protein, transporter, hydrolase
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 142484.64

Authors

McGrath, A.P.,Rees, S.D.,Chang, G. (deposition date: 2015-01-28, release date: 2016-04-27, Last modification date: 2023-09-27)

• Primary citation: Nicklisch, S.C.,Rees, S.D.,McGrath, A.P.,Gokirmak, T.,Bonito, L.T.,Vermeer, L.M.,Cregger, C.,Loewen, G.,Sandin, S.,Chang, G.,Hamdoun, A.; Global marine pollutants inhibit P-glycoprotein: Environmental levels, inhibitory effects, and cocrystal structure.; Sci Adv, 2:e1600001-e1600001, 2016; PubMed: 27152359; DOI: 10.1126/sciadv.1600001

Experimental method

X-RAY DIFFRACTION (3.5 Å)