4XW2
Structural basis for simvastatin competitive antagonism of complement receptor 3
Summary for 4XW2
Entry DOI | 10.2210/pdb4xw2/pdb |
Descriptor | Integrin alpha-M, MAGNESIUM ION, Simvastatin acid, ... (4 entities in total) |
Functional Keywords | immune system, complement receptor 3, rossmann fold, integrin, statin, protein-inhibitor complex, mac-1, i domain, vwa |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P11215 |
Total number of polymer chains | 1 |
Total formula weight | 22941.48 |
Authors | Bajic, G.,Jensen, M.R.,Vorup-Jensen, T.,Andersen, G.R. (deposition date: 2015-01-28, release date: 2016-01-13, Last modification date: 2024-01-10) |
Primary citation | Jensen, M.R.,Bajic, G.,Zhang, X.,Laustsen, A.K.,Kolds, H.,Skeby, K.K.,Schitt, B.,Andersen, G.R.,Vorup-Jensen, T. Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J.Biol.Chem., 291:16963-16976, 2016 Cited by PubMed: 27339893DOI: 10.1074/jbc.M116.732222 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.001 Å) |
Structure validation
Download full validation report