4XI9

Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2)

Summary for 4XI9

Entry DOI	10.2210/pdb4xi9/pdb
Descriptor	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Retinoblastoma-like protein 2, (2S,3R,4R,5S,6R)-3-(acetylamino)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-thiopyran-2-yl [(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate (3 entities in total)
Functional Keywords	o-glcnac transferase inverting gt-b substrate complex, transferase
Biological source	Homo sapiens (Human) More
Cellular location	Isoform 2: Mitochondrion. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm: O15294 Nucleus: Q08999
Total number of polymer chains	8
Total formula weight	329371.04
Authors	Schimpl, M.,van Aalten, D.M.F. (deposition date: 2015-01-06, release date: 2015-08-05, Last modification date: 2015-09-16)
Primary citation	Pathak, S.,Alonso, J.,Schimpl, M.,Rafie, K.,Blair, D.E.,Borodkin, V.S.,Schuttelkopf, A.W.,Albarbarawi, O.,van Aalten, D.M. The active site of O-GlcNAc transferase imposes constraints on substrate sequence. Nat.Struct.Mol.Biol., 22:744-750, 2015 Cited by PubMed: 26237509 DOI: 10.1038/nsmb.3063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation