4XI9
Human OGT in complex with UDP-5S-GlcNAc and substrate peptide (RBL2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0006493 | biological_process | protein O-linked glycosylation |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0006493 | biological_process | protein O-linked glycosylation |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0006493 | biological_process | protein O-linked glycosylation |
| D | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue 12V A 1200 |
| Chain | Residue |
| A | HIS498 |
| A | TYR841 |
| A | LYS842 |
| A | VAL895 |
| A | ALA896 |
| A | LYS898 |
| A | HIS901 |
| A | ARG904 |
| A | CYS917 |
| A | HIS920 |
| A | THR921 |
| A | PRO559 |
| A | THR922 |
| A | ASP925 |
| E | PRO1418 |
| E | VAL1419 |
| E | SER1420 |
| A | THR560 |
| A | LEU563 |
| A | LEU653 |
| A | GLY654 |
| A | PRO656 |
| A | PHE694 |
| A | GLN839 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue 12V B 1200 |
| Chain | Residue |
| B | HIS498 |
| B | HIS558 |
| B | PRO559 |
| B | THR560 |
| B | LEU653 |
| B | GLY654 |
| B | PRO656 |
| B | GLN839 |
| B | TYR841 |
| B | LYS842 |
| B | LEU866 |
| B | VAL895 |
| B | ALA896 |
| B | LYS898 |
| B | HIS901 |
| B | ARG904 |
| B | CYS917 |
| B | HIS920 |
| B | THR921 |
| B | THR922 |
| B | ASP925 |
| F | VAL1419 |
| F | SER1420 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | binding site for residue 12V C 1200 |
| Chain | Residue |
| C | HIS498 |
| C | PRO559 |
| C | THR560 |
| C | LEU563 |
| C | LEU653 |
| C | GLY654 |
| C | PHE694 |
| C | GLN839 |
| C | TYR841 |
| C | LYS842 |
| C | LEU866 |
| C | VAL895 |
| C | ALA896 |
| C | LYS898 |
| C | HIS901 |
| C | ARG904 |
| C | CYS917 |
| C | HIS920 |
| C | THR921 |
| C | THR922 |
| C | ASP925 |
| G | VAL1419 |
| G | SER1420 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue 12V D 1200 |
| Chain | Residue |
| D | HIS498 |
| D | HIS558 |
| D | PRO559 |
| D | THR560 |
| D | LEU653 |
| D | GLY654 |
| D | PRO656 |
| D | GLN839 |
| D | TYR841 |
| D | LYS842 |
| D | VAL895 |
| D | ALA896 |
| D | LYS898 |
| D | HIS901 |
| D | ARG904 |
| D | CYS917 |
| D | HIS920 |
| D | THR921 |
| D | THR922 |
| D | ASP925 |
| H | VAL1419 |
| H | SER1420 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"TPR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 132 |
| Details | Repeat: {"description":"TPR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Repeat: {"description":"TPR 13; truncated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 76 |
| Details | Region: {"description":"Required for phosphatidylinositol 3,4,5-triphosphate binding","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Motif: {"description":"DFP motif","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 64 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21240259","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26678539","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23103939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"PubMed","id":"24563466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine; by autocatalysis","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q64700","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"source":"PubMed","id":"26237509","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
