4XG3
Crystal structure of an inhibitor-bound Syk
Summary for 4XG3
Entry DOI | 10.2210/pdb4xg3/pdb |
Related | 4XG2 4XG4 4XG5 4XG6 4XG7 4XG8 4XG9 |
Descriptor | Tyrosine-protein kinase SYK, 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate (3 entities in total) |
Functional Keywords | syk kinase, inhibitor, spleen tyrosine kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane : P43405 |
Total number of polymer chains | 2 |
Total formula weight | 68781.06 |
Authors | |
Primary citation | Lee, S.J.,Choi, J.S.,Han, B.G.,Kim, H.S.,Song, H.J.,Lee, J.,Nam, S.,Goh, S.H.,Kim, J.H.,Koh, J.S.,Lee, B.I. Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283:3613-3625, 2016 Cited by PubMed: 27504936DOI: 10.1111/febs.13831 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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