4XDJ

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2)

4XDJ の概要

• エントリーDOI: 10.2210/pdb4xdj/pdb
• 関連するPDBエントリー: 4BW5
• 分子名称: POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... (4 entities in total)
• 機能のキーワード: transport protein, outward rectification, membrane protein, k2p, structural genomics, structural genomics consortium, sgc
• 由来する生物種: homo sapiens (human)
• 細胞内の位置: Membrane ; Multi-pass membrane protein : P57789
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128373.06

構造登録者

Pike, A.C.W.,Dong, Y.Y.,Mackenzie, A.,Mukhopadhyay, S.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Burgess-Brown, N.A.,Carpenter, E.P.,Structural Genomics Consortium (SGC) (登録日: 2014-12-19, 公開日: 2015-03-18, 最終更新日: 2024-01-10)

• 主引用文献: Dong, Y.Y.,Pike, A.C.,Mackenzie, A.,McClenaghan, C.,Aryal, P.,Dong, L.,Quigley, A.,Grieben, M.,Goubin, S.,Mukhopadhyay, S.,Ruda, G.F.,Clausen, M.V.,Cao, L.,Brennan, P.E.,Burgess-Brown, N.A.,Sansom, M.S.,Tucker, S.J.,Carpenter, E.P.; K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.; Science, 347:1256-1259, 2015; PubMed: 25766236; DOI: 10.1126/science.1261512

実験手法

X-RAY DIFFRACTION (3.8 Å)