4XAJ

Crystal structure of human NR2E1/TLX

Summary for 4XAJ

DescriptorMaltose-binding periplasmic protein,Nuclear receptor subfamily 2 group E member 1, Atrophin/grunge, MALTOSE (3 entities in total)
Functional Keywordshelical sanwich, transport protein-transcription complex, transport protein/transcription
Biological sourceEscherichia coli O157:H7
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Cellular locationNucleus  Q9Y466
Total number of polymer chains6
Total molecular weight259707.37
Authors
Zhi, X.,Zhou, E.,Xu, E. (deposition date: 2014-12-14, release date: 2015-03-04, Last modification date: 2015-07-29)
Primary citation
Zhi, X.,Zhou, X.E.,He, Y.,Searose-Xu, K.,Zhang, C.L.,Tsai, C.C.,Melcher, K.,Xu, H.E.
Structural basis for corepressor assembly by the orphan nuclear receptor TLX.
Genes Dev., 29:440-450, 2015
PubMed: 25691470 (PDB entries with the same primary citation)
DOI: 10.1101/gad.254904.114
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.551 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.32220.3%0.2%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 4xaj
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Molmil generated image of 4xaj
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (4xaj.pdb2.gz [385.32 KB])
Coordinate files for Biological unit (4xaj.pdb1.gz [381.99 KB])