4X8T

FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 7-chloro-3,4-dihydroisoquinolin-1(2H)-one

Summary for 4X8T

Related4X8S 4X8U 4X8V
DescriptorFactor VIIa (Heavy Chain), Factor VIIa (Light Chain), 7-chloro-3,4-dihydroisoquinolin-1(2H)-one, ... (7 entities in total)
Functional Keywordsglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted P08709 P08709
Total number of polymer chains2
Total molecular weight34736.06
Authors
Wei, A. (deposition date: 2014-12-10, release date: 2015-03-25, Last modification date: 2015-04-08)
Primary citation
Cheney, D.L.,Bozarth, J.M.,Metzler, W.J.,Morin, P.E.,Mueller, L.,Newitt, J.A.,Nirschl, A.H.,Rendina, A.R.,Tamura, J.K.,Wei, A.,Wen, X.,Wurtz, N.R.,Seiffert, D.A.,Wexler, R.R.,Priestley, E.S.
Discovery of Novel P1 Groups for Coagulation Factor VIIa Inhibition Using Fragment-Based Screening.
J.Med.Chem., 58:2799-2808, 2015
PubMed: 25764119 (PDB entries with the same primary citation)
DOI: 10.1021/jm501982k
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222002.0%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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