4X8T

FACTOR VIIA IN COMPLEX WITH THE INHIBITOR 7-chloro-3,4-dihydroisoquinolin-1(2H)-one

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 3Z8 H 301

Chain	Residue
H	ASP189
H	CYS220
H	GLY226
H	SER190
H	LYS192
H	SER195
H	VAL213
H	SER214
H	TRP215
H	GLY216
H	GLY219

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site_id	AC2
Number of Residues	6
Details	binding site for residue CA H 302

Chain	Residue
H	GLU70
H	ASP72
H	GLU75
H	GLU80
H	HOH401
H	HOH419

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 H 303

Chain	Residue
H	ARG83
H	ARG84
H	HIS109
H	GLN110

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 H 304

Chain	Residue
H	VAL35
H	ASN37
H	LYS60
H	ILE60
H	LYS60
H	ASN60

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 H 305

Chain	Residue
H	ILE47
H	ASN48
H	GLN239
H	HOH424
L	HIS115
L	GLU116

---

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL H 306

Chain	Residue
H	TRP61
H	PRO96
H	ARG147
H	LEU251
H	HOH429

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC

Chain	Residue	Details
H	VAL53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPHA

Chain	Residue	Details
H	ASP189-ALA200

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site_id	PS01186
Number of Residues	16
Details	EGF_2 EGF-like domain signature 2. CrCheGYslladgvsC

Chain	Residue	Details
L	CYS112-CYS127

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
H	ASP189

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329, ECO:0000269|PubMed:3264725

Chain	Residue	Details
H	ASN175

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