4WXH

Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T

4WXH の概要

• エントリーDOI: 10.2210/pdb4wxh/pdb
• 関連するPDBエントリー: 1TW2 1TW3
• 分子名称: Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, ... (6 entities in total)
• 機能のキーワード: methyltransferase, mono-oxygenase, sah binding, antibiotic binding, transferase
• 由来する生物種: Streptomyces peucetius
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82939.58

構造登録者

Metsa-Ketela, M.,Niiranen, L. (登録日: 2014-11-13, 公開日: 2015-07-29, 最終更新日: 2024-01-10)

• 主引用文献: Grocholski, T.,Dinis, P.,Niiranen, L.,Niemi, J.,Metsa-Ketela, M.; Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.; Proc.Natl.Acad.Sci.USA, 112:9866-9871, 2015; PubMed: 26216966; DOI: 10.1073/pnas.1501765112

実験手法

X-RAY DIFFRACTION (1.9 Å)