4WUA

Crystal structure of human SRPK1 complexed to an inhibitor SRPIN340

4WUA の概要

• エントリーDOI: 10.2210/pdb4wua/pdb
• 分子名称: SRSF protein kinase 1, linker, SRSF protein kinase 1, N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]-4-pyridinecarboxamide, CITRIC ACID, ... (4 entities in total)
• 機能のキーワード: protein kinase, kinase-inhibitor complex, pre-mrna splicing, atp-binding, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46180.54

構造登録者

Hoshina, M.,Ikura, T.,Hosoya, T.,Hagiwara, M.,Ito, N. (登録日: 2014-10-31, 公開日: 2015-09-16, 最終更新日: 2023-11-08)

• 主引用文献: Morooka, S.,Hoshina, M.,Kii, I.,Okabe, T.,Kojima, H.,Inoue, N.,Okuno, Y.,Denawa, M.,Yoshida, S.,Fukuhara, J.,Ninomiya, K.,Ikura, T.,Furuya, T.,Nagano, T.,Noda, K.,Ishida, S.,Hosoya, T.,Ito, N.,Yoshimura, N.,Hagiwara, M.; Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice; Mol.Pharmacol., 88:316-325, 2015; PubMed: 25993998; DOI: 10.1124/mol.114.097345

実験手法

X-RAY DIFFRACTION (2 Å)