4WNK
Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022
Summary for 4WNK
Entry DOI | 10.2210/pdb4wnk/pdb |
Related | 3NYN 4MKO |
Descriptor | G protein-coupled receptor kinase 5, (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | g protein-coupled receptor kinase 5, hydrolase, phosphorylation, cardiovascular disease, ligase |
Biological source | Bos taurus (Bovine) |
Total number of polymer chains | 1 |
Total formula weight | 69633.42 |
Authors | Homan, K.T.,Tesmer, J.J.G. (deposition date: 2014-10-13, release date: 2015-06-10, Last modification date: 2023-09-27) |
Primary citation | Homan, K.T.,Waldschmidt, H.V.,Glukhova, A.,Cannavo, A.,Song, J.,Cheung, J.Y.,Koch, W.J.,Larsen, S.D.,Tesmer, J.J. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J.Biol.Chem., 290:20649-20659, 2015 Cited by PubMed: 26032411DOI: 10.1074/jbc.M115.647370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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