4WEF

Structure of the Hemagglutinin-neuraminidase from Human parainfluenza virus type III: complex with difluorosialic acid

Summary for 4WEF

• Entry DOI: 10.2210/pdb4wef/pdb
• Related: 1V3C 4WEG
• Descriptor: Hemagglutinin-neuraminidase glycoprotein, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: neuraminidase, hpiv3 hn, complex, difluorosialic acid, covalent inhibitor, second receptor binding site, viral protein
• Biological source: Human parainfluenza virus 3
• Total number of polymer chains: 2
• Total formula weight: 102825.98

Authors

Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J. (deposition date: 2014-09-10, release date: 2015-09-16, Last modification date: 2023-11-08)

• Primary citation: Streltsov, V.A.,Pilling, P.,Barrett, S.,McKimm-Breschkin, J.L.; Catalytic mechanism and novel receptor binding sites of human parainfluenza virus type 3 hemagglutinin-neuraminidase (hPIV3 HN); Antiviral Res., 123:216-223, 2015; PubMed: 26364554; DOI: 10.1016/j.antiviral.2015.08.014

Experimental method

X-RAY DIFFRACTION (2.5 Å)