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4W5R

The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)

Summary for 4W5R
Entry DOI10.2210/pdb4w5r/pdb
Related4W5N 4W5O 4W5Q 4W5T
DescriptorProtein argonaute-2, RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*UP*U)-3'), RNA (5'-R(P*AP*AP*UP*GP*UP*GP*AP*AP*A)-3'), ... (7 entities in total)
Functional Keywordsago2, guide, target, seed, rnase, rnai, microrna, hydrolase-rna complex, hydrolase/rna
Biological sourceHomo sapiens (Human)
More
Cellular locationCytoplasm, P-body : Q9UKV8
Total number of polymer chains3
Total formula weight108549.78
Authors
Schirle, N.T.,MacRae, I.J. (deposition date: 2014-08-18, release date: 2014-11-12, Last modification date: 2023-09-27)
Primary citationSchirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J.
Gene regulation. Structural basis for microRNA targeting.
Science, 346:608-613, 2014
Cited by
PubMed: 25359968
DOI: 10.1126/science.1258040
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

217705

数据于2024-03-27公开中

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