4UYA

Structure of MLK4 kinase domain with ATPgammaS

Summary for 4UYA

Entry DOI	10.2210/pdb4uya/pdb
Related	4UY9
Descriptor	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE MLK4, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	mixed-lineage kinase, atp-binding, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, sh3 domain, transferase, leucine zipper 1
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	39045.09
Authors	Read, J.A.,Brassington, C.,Pollard, H.K.,Phillips, C.,Green, I.,Overmann, R.,Collier, M. (deposition date: 2014-08-29, release date: 2015-09-30, Last modification date: 2024-01-10)
Primary citation	Marusiak, A.A.,Stephenson, N.L.,Baik, H.,Trotter, E.W.,Li, Y.,Blyth, K.,Mason, S.,Chapman, P.,Puto, L.A.,Read, J.A.,Brassington, C.,Pollard, H.K.,Phillips, C.,Green, I.,Overman, R.,Collier, M.,Testoni, E.,Miller, C.,Hunter, T.,Sansom, O.J.,Brognard, J. Recurrent Mlk4 Loss-of-Function Mutations Suppress Jnk Signaling to Promote Colon Tumorigenesis. Cancer Res., 76:724-, 2016 Cited by PubMed: 26637668 DOI: 10.1158/0008-5472.CAN-15-0701-T PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation