4UV7

The complex structure of extracellular domain of EGFR and GC1118A

4UV7 の概要

• エントリーDOI: 10.2210/pdb4uv7/pdb
• 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, GC1118A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: transferase, receptor tyrosine kinase, antibody
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 118519.41

構造登録者

Yoo, J.H.,Cho, H.S. (登録日: 2014-08-05, 公開日: 2015-10-14, 最終更新日: 2024-01-10)

• 主引用文献: Lim, Y.,Yoo, J.,Kim, M.S.,Hur, M.,Lee, E.H.,Hur, H.S.,Lee, J.C.,Lee, S.N.,Park, T.W.,Lee, K.,Chang, K.H.,Kim, K.,Kang, Y.,Hong, K.W.,Kim, S.H.,Kim, Y.G.,Yoon, Y.,Nam, D.H.,Yang, H.,Kim, D.G.,Cho, H.S.,Won, J.; Gc1118, an Anti-Egfr Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity Against High-Affinity Egfr Ligands.; Mol.Cancer Ther., 15:251-, 2016; PubMed: 26586721; DOI: 10.1158/1535-7163.MCT-15-0679

実験手法

X-RAY DIFFRACTION (2.1 Å)