4UTB

Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11

Summary for 4UTB

• Entry DOI: 10.2210/pdb4utb/pdb
• Related: 4UTA 4UTC
• Descriptor: ENVELOPE GLYCOPROTEIN E, BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: immune system-viral protein complex, viral protein, membrane fusion, class 2 fusion protein, dengue virus, broadly neutralizing antibody, immune system, fab fragment, immune system/viral protein
• Biological source: DENGUE VIRUS 2; More
• Total number of polymer chains: 6
• Total formula weight: 203511.13

Authors

Rouvinski, A.,Guardado-Calvo, P.,Barba-Spaeth, G.,Duquerroy, S.,Vaney, M.C.,Rey, F.A. (deposition date: 2014-07-18, release date: 2015-01-28, Last modification date: 2024-01-10)

• Primary citation: Rouvinski, A.,Guardado-Calvo, P.,Barba-Spaeth, G.,Duquerroy, S.,Vaney, M.,Kikuti, C.M.,Sanchez, M.E.N.,Dejnirattisai, W.,Wongwiwat, W.,Haouz, A.,Girard-Blanc, C.,Petres, S.,Shepard, W.E.,Despres, P.,Arenzana-Seisdedos, F.,Dussart, P.,Mongkolsapaya, J.,Screaton, G.R.,Rey, F.A.; Recognition Determinants of Broadly Neutralizing Human Antibodies Against Dengue Viruses.; Nature, 520:109-, 2015; PubMed: 25581790; DOI: 10.1038/NATURE14130

Experimental method

X-RAY DIFFRACTION (3.85 Å)