4UTB
Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE2 A11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | ENVELOPE GLYCOPROTEIN E | polymer | 422 | 46816.5 | 2 | UniProt (Q68Y26) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (A0A0B4SHY9) In PDB | DENGUE VIRUS 2 | |
| 2 | H, I | BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 | polymer | 283 | 30355.5 | 2 | HOMO SAPIENS (HUMAN) | ||
| 3 | L, M | BROADLY NEUTRALIZING HUMAN ANTIBODY EDE2 A11 | polymer | 218 | 23107.7 | 2 | HOMO SAPIENS (HUMAN) | ||
| 4 | C, E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 2 | In PDB GlyTouCan (G82348BZ) | |||
| 5 | D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | H, I | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 391 (UniProt: Q68Y26)
| PDB | External Database | Details |
|---|---|---|
| Leu 1392 | - | expression tag |
| Arg 1393 | - | expression tag |
| Pro 1394 | - | expression tag |
| Leu 1395 | - | expression tag |
| Glu 1396 | - | expression tag |
| Ser 1397 | - | expression tag |
| Arg 1398 | - | expression tag |
| Gly 1399 | - | expression tag |
| Pro 1400 | - | expression tag |
| Phe 1401 | - | expression tag |
| Glu 1402 | - | expression tag |
| Gly 1403 | - | expression tag |
| Lys 1404 | - | expression tag |
| Pro 1405 | - | expression tag |
| Ile 1406 | - | expression tag |
| Pro 1407 | - | expression tag |
| Asn 1408 | - | expression tag |
| Pro 1409 | - | expression tag |
| Leu 1410 | - | expression tag |
| Leu 1411 | - | expression tag |
| Gly 1412 | - | expression tag |
| Leu 1413 | - | expression tag |
| Asp 1414 | - | expression tag |
| Ser 1415 | - | expression tag |
| Thr 1416 | - | expression tag |
| Arg 1417 | - | expression tag |
| Thr 1418 | - | expression tag |
| Gly 1419 | - | expression tag |
| His 1420 | - | expression tag |
| His 1421 | - | expression tag |
| His 1422 | - | expression tag |
| Lys 118 | Met 398 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 200559.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2538.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 413.3 | |
| All* | Total formula weight | 203511.1 |
