4UP3
Crystal structure of the mutant C140S,C286Q thioredoxin reductase from Entamoeba histolytica
Summary for 4UP3
Entry DOI | 10.2210/pdb4up3/pdb |
Descriptor | THIOREDOXIN REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | oxidoreductase, redox metabolism, oxidative stress |
Biological source | ENTAMOEBA HISTOLYTICA |
Total number of polymer chains | 2 |
Total formula weight | 70701.06 |
Authors | Podust, L.M.,Vieira, D.F. (deposition date: 2014-06-11, release date: 2015-07-01, Last modification date: 2024-01-10) |
Primary citation | Parsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M. X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194:180-, 2016 Cited by PubMed: 26876147DOI: 10.1016/J.JSB.2016.02.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.44 Å) |
Structure validation
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