4UP3

Crystal structure of the mutant C140S,C286Q thioredoxin reductase from Entamoeba histolytica

Summary for 4UP3

Entry DOI	10.2210/pdb4up3/pdb
Descriptor	THIOREDOXIN REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	oxidoreductase, redox metabolism, oxidative stress
Biological source	ENTAMOEBA HISTOLYTICA
Total number of polymer chains	2
Total formula weight	70701.06
Authors	Podust, L.M.,Vieira, D.F. (deposition date: 2014-06-11, release date: 2015-07-01, Last modification date: 2024-01-10)
Primary citation	Parsonage, D.,Sheng, F.,Hirata, K.,Debnath, A.,Mckerrow, J.H.,Reed, S.L.,Abagyan, R.,Poole, L.B.,Podust, L.M. X-Ray Structures of Thioredoxin and Thioredoxin Reductase from Entamoeba Histolytica and Prevailing Hypothesis of the Mechanism of Auranofin Action. J.Struct.Biol., 194:180-, 2016 Cited by PubMed: 26876147 DOI: 10.1016/J.JSB.2016.02.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.44 Å)

Structure validation