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4UP3

Crystal structure of the mutant C140S,C286Q thioredoxin reductase from Entamoeba histolytica

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0016491molecular_functionoxidoreductase activity
A0019430biological_processremoval of superoxide radicals
A0045454biological_processcell redox homeostasis
B0000166molecular_functionnucleotide binding
B0004791molecular_functionthioredoxin-disulfide reductase (NADPH) activity
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0016491molecular_functionoxidoreductase activity
B0019430biological_processremoval of superoxide radicals
B0045454biological_processcell redox homeostasis
Functional Information from PDB Data
site_idAC1
Number of Residues44
DetailsBINDING SITE FOR RESIDUE FAD A 1315
ChainResidue
AILE10
AALA38
AVAL41
AALA42
AALA43
AGLY45
AGLN46
ALEU47
ATHR49
ATHR50
AILE53
AGLY11
AASN55
ATHR87
AILE88
AALA116
ATHR117
AGLY118
AALA119
AHIS248
AGLY283
AASP284
ASER12
AARG291
AGLN292
AALA293
AALA296
ANDP1316
AHOH2015
AHOH2038
AHOH2064
AHOH2070
AHOH2074
AGLY13
AHOH2079
AHOH2193
AHOH2194
AHOH2413
BTYR22
APRO14
AALA15
ATYR33
AGLU34
AGLY35

site_idAC2
Number of Residues41
DetailsBINDING SITE FOR RESIDUE FAD B 1315
ChainResidue
ATYR22
AHOH2025
BILE10
BGLY11
BSER12
BGLY13
BPRO14
BALA15
BTYR33
BGLU34
BGLY35
BALA38
BVAL41
BALA42
BALA43
BGLY45
BGLN46
BLEU47
BTHR50
BILE53
BASN55
BTHR87
BILE88
BALA116
BTHR117
BGLY118
BALA119
BGLY283
BASP284
BARG291
BGLN292
BALA293
BALA296
BHOH2016
BHOH2038
BHOH2051
BHOH2057
BHOH2061
BHOH2139
BHOH2140
BHOH2345

site_idAC3
Number of Residues27
DetailsBINDING SITE FOR RESIDUE NDP A 1316
ChainResidue
AHOH2238
AHOH2239
AHOH2240
AHOH2250
AHOH2259
AHOH2261
AHOH2324
AHOH2325
AHOH2414
AHOH2415
AHOH2416
AHOH2417
BARG183
AGLY160
AGLY161
AASP162
AALA163
AGLU166
AHIS182
AARG183
AARG184
AARG188
AALA245
AILE246
AFAD1315
AHOH2199
AHOH2208

site_idAC4
Number of Residues33
DetailsBINDING SITE FOR RESIDUE NDP B 1316
ChainResidue
BLYS122
BGLY160
BGLY161
BASP162
BALA163
BGLU166
BHIS182
BARG183
BARG184
BARG188
BALA245
BILE246
BHIS248
BTYR290
BARG291
BGLN292
BHOH2146
BHOH2178
BHOH2179
BHOH2180
BHOH2189
BHOH2190
BHOH2193
BHOH2206
BHOH2207
BHOH2265
BHOH2269
BHOH2324
BHOH2344
BHOH2346
BHOH2347
BHOH2348
BHOH2349

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B 1317
ChainResidue
BLEU268
BSER275
BHOH2350

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PDB entries from 2024-10-30

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