4UP3
Crystal structure of the mutant C140S,C286Q thioredoxin reductase from Entamoeba histolytica
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | THIOREDOXIN REDUCTASE | polymer | 314 | 33788.5 | 2 | UniProt (C4LW95) Pfam (PF07992) | ENTAMOEBA HISTOLYTICA | |
| 2 | C, E (A, B) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | D, F (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | G (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 767 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 314 (UniProt: C4LW95)
| PDB | External Database | Details |
|---|---|---|
| Ser 140 | Cys 140 | engineered mutation |
| Gln 286 | Cys 286 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67577.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3124.0 | |
| All* | Total formula weight | 70701.1 |
