4UMT
Structure of MELK in complex with inhibitors
Summary for 4UMT
Entry DOI | 10.2210/pdb4umt/pdb |
Related | 4UMP 4UMQ 4UMR 4UMU |
Descriptor | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, DIMETHYL SULFOXIDE, 1-(4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}-2-methoxybenzyl)piperazinediium, ... (4 entities in total) |
Functional Keywords | transferase, fragment based drug design |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Peripheral membrane protein : Q14680 |
Total number of polymer chains | 1 |
Total formula weight | 41389.92 |
Authors | Johnson, C.N.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,McMenamin, R.,Patel, S.,Rees, D.C.,Sharff, A.,Sommen, F.,Wu, T.,Linders, J.T.M. (deposition date: 2014-05-21, release date: 2014-10-22, Last modification date: 2024-05-08) |
Primary citation | Johnson, C.N.,Adelinet, C.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Calo, F.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,Mevellec, L.,Mcmenamin, R.,Pasquier, E.,Patel, S.,Rees, D.C.,Linders, J.T.M. Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase. Acs Med.Chem.Lett., 6:31-, 2015 Cited by PubMed: 25589926DOI: 10.1021/ML5001273 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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