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4UMU

Structure of MELK in complex with inhibitors

Summary for 4UMU
Entry DOI10.2210/pdb4umu/pdb
Related4UMP 4UMQ 4UMR 4UMT
DescriptorMATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, (2-ethoxy-4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}phenyl)methanaminium (3 entities in total)
Functional Keywordstransferase, fragment based drug design, kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCell membrane ; Peripheral membrane protein : Q14680
Total number of polymer chains1
Total formula weight41255.71
Authors
Primary citationJohnson, C.N.,Adelinet, C.,Berdini, V.,Beke, L.,Bonnet, P.,Brehmer, D.,Calo, F.,Coyle, J.E.,Day, P.J.,Frederickson, M.,Freyne, E.J.E.,Gilissen, R.A.H.J.,Hamlett, C.C.F.,Howard, S.,Meerpoel, L.,Mevellec, L.,Mcmenamin, R.,Pasquier, E.,Patel, S.,Rees, D.C.,Linders, J.T.M.
Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.
Acs Med.Chem.Lett., 6:31-, 2015
Cited by
PubMed: 25589926
DOI: 10.1021/ML5001273
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

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