4UMT
Structure of MELK in complex with inhibitors
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE | polymer | 356 | 40922.3 | 1 | UniProt (Q14680) Pfam (PF00069) Pfam (PF21594) In PDB | HOMO SAPIENS (HUMAN) | HMELK, PROTEIN KINASE EG3, PEG3 KINASE, PROTEIN KINASE PK38, HPK38, TYROSINE-PROTEIN KINASE MELK |
2 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
3 | A | 1-(4-{[3-(isoquinolin-7-yl)prop-2-yn-1-yl]oxy}-2-methoxybenzyl)piperazinediium | non-polymer | 389.5 | 1 | Chemie (47W) | |||
4 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A: 1 - 336 (UniProt: Q14680)
PDB | External Database | Details |
---|---|---|
Met -19 | - | expression tag |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Thr 213 | Asn 213 | engineered mutation |
Ala 214 | Val 214 | engineered mutation |
Ala 215 | Met 215 | engineered mutation |
Val 218 | Tyr 218 | engineered mutation |
Ala 219 | Lys 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40922.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 467.6 | |
All* | Total formula weight | 41389.9 |