4UMM

The Cryo-EM structure of the palindromic DNA-bound USP-EcR nuclear receptor reveals an asymmetric organization with allosteric domain positioning

Summary for 4UMM

• Entry DOI: 10.2210/pdb4umm/pdb
• EMDB information: 2631
• Descriptor: ECR-USP, 5'-D(*CP*AP*AP*GP*GP*GP*TP*TP*CP*AP*AP*TP*GP*CP *AP*CP*TP*TP*GP*TP)-3', 5'-D(*DGP*AP*CP*AP*AP*GP*TP*GP*CP*AP*TP*TP*GP*DAP *AP*CP*CP*CP*TP*T)-3', ... (9 entities in total)
• Functional Keywords: nuclear receptor, transcription, ecdysone, usp-ecr, dna response element, allostery, cryo electron microscopy
• Biological source: HELIOTHIS VIRESCENS (TOBACCO BUDWORM); More
• Total number of polymer chains: 6
• Total formula weight: 93129.98

Authors

Maletta, M.,Orlov, I.,Moras, D.,Billas, I.M.L.,Klaholz, B.P. (deposition date: 2014-05-19, release date: 2014-06-25, Last modification date: 2024-05-08)

• Primary citation: Maletta, M.,Orlov, I.,Moras, D.,Billas, I.M.L.,Klaholz, B.P.; The Palindromic DNA-Bound Usp-Ecr Nuclear Receptor Adopts an Asymmetric Organization with Allosteric Domain Positioning.; Nat.Commun., 5:4139-, 2014; PubMed: 24942373; DOI: 10.1038/NCOMMS5139

Experimental method

ELECTRON MICROSCOPY (11.6 Å)