4UMM
The Cryo-EM structure of the palindromic DNA-bound USP-EcR nuclear receptor reveals an asymmetric organization with allosteric domain positioning
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003707 | molecular_function | nuclear steroid receptor activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0006351 | biological_process | DNA-templated transcription |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0030518 | biological_process | nuclear receptor-mediated steroid hormone signaling pathway |
| G | 0003677 | molecular_function | DNA binding |
| G | 0004879 | molecular_function | nuclear receptor activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0006355 | biological_process | regulation of DNA-templated transcription |
| G | 0035076 | biological_process | ecdysone receptor signaling pathway |
| G | 0035100 | molecular_function | ecdysone binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE P1A G 1530 |
| Chain | Residue |
| G | GLU309 |
| G | LEU396 |
| G | PHE397 |
| G | ALA398 |
| G | TYR408 |
| G | MET413 |
| G | VAL416 |
| G | LEU420 |
| G | ASN504 |
| G | GLN310 |
| G | ILE339 |
| G | MET342 |
| G | THR343 |
| G | THR346 |
| G | ARG383 |
| G | VAL384 |
| G | ARG387 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE EPH F 1456 |
| Chain | Residue |
| F | LEU230 |
| F | VAL238 |
| F | PRO239 |
| F | PHE242 |
| F | LEU249 |
| F | ASN287 |
| F | LEU290 |
| F | MET323 |
| F | LEU331 |
| F | GLN338 |
| F | ALA339 |
| F | SER431 |
| F | HIS434 |
| F | PHE438 |
| F | LEU440 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. ClvCg.Drasgy.HYnaltCegCkgFFrR |
| Chain | Residue | Details |
| E | CYS147-ARG173 | |
| A | CYS113-ARG139 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 72 |
| Details | DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
