4UM3

Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3920

Summary for 4UM3

• Entry DOI: 10.2210/pdb4um3/pdb
• Related: 4UM1
• Descriptor: ACETYLCHOLINE BINDING PROTEIN, 1-(6-bromopyridin-3-yl)-1,4-diazepane, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: nicotinic acetylcholine receptor, ion channel, receptor stoichiometry, cys-loop receptor, signaling protein
• Biological source: LYMNAEA STAGNALIS (GREAT POND SNAIL); More
• Cellular location: Secreted: P58154 P58154 P58154
• Total number of polymer chains: 40
• Total formula weight: 1053015.01

Authors

Shahsavar, A.,Kastrup, J.S.,Balle, T.,Gajhede, M. (deposition date: 2014-05-14, release date: 2015-07-22, Last modification date: 2024-01-10)

• Primary citation: Shahsavar, A.,Ahring, P.K.,Olsen, J.A.,Krintel, C.,Kastrup, J.S.,Balle, T.,Gajhede, M.; Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity; Mol.Pharmacol., 88:697-, 2015; PubMed: 26180047; DOI: 10.1124/MOL.115.098061

Experimental method

X-RAY DIFFRACTION (2.703 Å)