4UM1

Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3573

Summary for 4UM1

Entry DOI	10.2210/pdb4um1/pdb
Related	4UM3
Descriptor	ACETYLCHOLINE-BINDING PROTEIN, 1-(5-ethoxypyridin-3-yl)-1,4-diazepane, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	signaling protein, ion channel, receptor stoichiometry, cys-loop receptor, acetylcholine binding protein
Biological source	LYMNAEA STAGNALIS (GREAT POND SNAIL)
Cellular location	Secreted: P58154
Total number of polymer chains	5
Total formula weight	131593.42
Authors	Shahsavar, A.,Kastrup, J.S.,Balle, T.,Gajhede, M. (deposition date: 2014-05-14, release date: 2015-07-22, Last modification date: 2024-01-10)
Primary citation	Shahsavar, A.,Ahring, P.K.,Olsen, J.A.,Krintel, C.,Kastrup, J.S.,Balle, T.,Gajhede, M. Achbp Engineered to Mimic the Alpha4-Alpha4 Binding Pocket in Alpha4Beta2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity Mol.Pharmacol., 88:697-, 2015 Cited by PubMed: 26180047 DOI: 10.1124/MOL.115.098061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.83 Å)

Structure validation