4UM1
Engineered Ls-AChBP with alpha4-alpha4 binding pocket in complex with NS3573
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | ACETYLCHOLINE-BINDING PROTEIN | polymer | 229 | 26053.1 | 5 | UniProt (P58154) Pfam (PF02931) | LYMNAEA STAGNALIS (GREAT POND SNAIL) | ACH-BINDING PROTEIN, ACHBP |
| 2 | F, G, H, I, K (A, B, C, D, E) | 1-(5-ethoxypyridin-3-yl)-1,4-diazepane | non-polymer | 221.3 | 5 | Chemie (09P) | |||
| 3 | J (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 4 | L, M, N, O, P (A, B, C, D, E) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: -18 - 210 (UniProt: P58154)
| PDB | External Database | Details |
|---|---|---|
| His 104 | Arg 123 | engineered mutation |
| Gln 112 | Leu 131 | engineered mutation |
| Thr 114 | Met 133 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 130265.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1327.7 | |
| All* | Total formula weight | 131593.4 |
