DNA polymerase beta reactant complex with a templating adenine and incoming 8-oxodGTP, 20 s

Summary for 4UAZ

Related4UAW 4UAY 4UB1 4UB2 4UB3 4UB4 4UB5 4UBB 4UBC
Descriptor5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*(8OG))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (8 entities in total)
Functional Keywordsdna polymerase, transferase, lyase-dna complex, lyase/dna
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P06746
Total number of polymer chains4
Total molecular weight48786.84
Freudenthal, B.D.,Wilson, S.H.,Beard, W.A. (deposition date: 2014-08-11, release date: 2014-11-12, Last modification date: 2015-02-04)
Primary citation
Freudenthal, B.D.,Beard, W.A.,Perera, L.,Shock, D.D.,Kim, T.,Schlick, T.,Wilson, S.H.
Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.
Nature, 517:635-639, 2015
PubMed: 25409153 (PDB entries with the same primary citation)
DOI: 10.1038/nature13886
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.216300.4%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution