4UB5

DNA polymerase beta substrate complex with a templating cytosine, incoming 8-oxodGTP, and Mn2+, 5 s

Summary for 4UB5

• Entry DOI: 10.2210/pdb4ub5/pdb
• Related: 4UAW 4UAY 4UAZ 4UB1 4UB2 4UB3 4UB4 4UBB 4UBC
• Descriptor: 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... (8 entities in total)
• Functional Keywords: dna polymerase, transferase, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48511.69

Authors

Freudenthal, B.D.,Wilson, S.H.,Beard, W.A. (deposition date: 2014-08-11, release date: 2014-11-12, Last modification date: 2023-09-27)

• Primary citation: Freudenthal, B.D.,Beard, W.A.,Perera, L.,Shock, D.D.,Kim, T.,Schlick, T.,Wilson, S.H.; Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.; Nature, 517:635-639, 2015; PubMed: 25409153; DOI: 10.1038/nature13886

Experimental method

X-RAY DIFFRACTION (2.15 Å)