4U1S

HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes

Summary for 4U1S

• Entry DOI: 10.2210/pdb4u1s/pdb
• Related: 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N
• Descriptor: HLA class I histocompatibility antigen, B-81 alpha chain, Beta-2-microglobulin, Vpr protein, ... (7 entities in total)
• Functional Keywords: immunoglobulin, hla, hiv, immune system
• Biological source: Homo sapiens (Human); More
• Cellular location: Membrane; Single-pass type I membrane protein: Q31610; Secreted . Note=(Microbial infection) In the presence of M: P61769
• Total number of polymer chains: 3
• Total formula weight: 46082.01

Authors

Rizkallah, P.J.,Cole, D.K.,Fuller, A.,Sewell, A.K. (deposition date: 2014-07-16, release date: 2015-04-08, Last modification date: 2023-12-20)

Primary citation

Klverpris, H.N.,Cole, D.K.,Fuller, A.,Carlson, J.,Beck, K.,Schauenburg, A.J.,Rizkallah, P.J.,Buus, S.,Sewell, A.K.,Goulder, P.
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.
Retrovirology, 12:20-20, 2015

PubMed Abstract: Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown.

PubMed: 25808313
DOI: 10.1186/s12977-015-0149-5

Experimental method

X-RAY DIFFRACTION (1.76 Å)