4U1L

HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes

Summary for 4U1L

Related4U1I 4U1J 4U1K 4U1H 4U1M 4U1N 4U1S
DescriptorHLA class I histocompatibility antigen, B-81 alpha chain, Beta-2-microglobulin, Protein Nef, ... (7 entities in total)
Functional Keywordsimmunoglobulin, hla, hiv, immune system
Biological sourceHomo sapiens (Human)
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Cellular locationMembrane; Single-pass type I membrane protein Q31610
Secreted . Note=(Microbial infection) In the presence of M P61769
Total number of polymer chains6
Total molecular weight91651.6
Authors
Rizkallah, P.J.,Cole, D.K.,Fuller, A.,Sewell, A.K. (deposition date: 2014-07-15, release date: 2015-04-08, Last modification date: 2017-08-30)
Primary citation
Klverpris, H.N.,Cole, D.K.,Fuller, A.,Carlson, J.,Beck, K.,Schauenburg, A.J.,Rizkallah, P.J.,Buus, S.,Sewell, A.K.,Goulder, P.
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.
Retrovirology, 12:20-20, 2015
PubMed: 25808313 (PDB entries with the same primary citation)
DOI: 10.1186/s12977-015-0149-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.06 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.21451.1%6.6%9.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report