4U1M
HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes
Summary for 4U1M
Entry DOI | 10.2210/pdb4u1m/pdb |
Related | 4U1I 4U1K |
Descriptor | HLA class I histocompatibility antigen, B-42 alpha chain, Beta-2-microglobulin, Protein Nef, ... (6 entities in total) |
Functional Keywords | immunoglobulin, hla, hiv, immune system |
Biological source | Homo sapiens (Human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P30480 Secreted . Note=(Microbial infection) In the presence of M: P61769 |
Total number of polymer chains | 3 |
Total formula weight | 46973.91 |
Authors | Rizkallah, P.J.,Cole, D.K.,Fuller, A.,Sewell, A.K. (deposition date: 2014-07-15, release date: 2015-04-08, Last modification date: 2024-10-16) |
Primary citation | Klverpris, H.N.,Cole, D.K.,Fuller, A.,Carlson, J.,Beck, K.,Schauenburg, A.J.,Rizkallah, P.J.,Buus, S.,Sewell, A.K.,Goulder, P. A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology, 12:20-20, 2015 Cited by PubMed Abstract: Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown. PubMed: 25808313DOI: 10.1186/s12977-015-0149-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.18 Å) |
Structure validation
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