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4U1M

HLA class I micropolymorphisms determine peptide-HLA landscape and dictate differential HIV-1 escape through identical epitopes

Summary for 4U1M
Entry DOI10.2210/pdb4u1m/pdb
Related4U1I 4U1K
DescriptorHLA class I histocompatibility antigen, B-42 alpha chain, Beta-2-microglobulin, Protein Nef, ... (6 entities in total)
Functional Keywordsimmunoglobulin, hla, hiv, immune system
Biological sourceHomo sapiens (Human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P30480
Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains3
Total formula weight46973.91
Authors
Rizkallah, P.J.,Cole, D.K.,Fuller, A.,Sewell, A.K. (deposition date: 2014-07-15, release date: 2015-04-08, Last modification date: 2024-10-16)
Primary citationKlverpris, H.N.,Cole, D.K.,Fuller, A.,Carlson, J.,Beck, K.,Schauenburg, A.J.,Rizkallah, P.J.,Buus, S.,Sewell, A.K.,Goulder, P.
A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape.
Retrovirology, 12:20-20, 2015
Cited by
PubMed Abstract: Presentation of identical HIV-1 peptides by closely related Human Leukocyte Antigen class I (HLAI) molecules can select distinct patterns of escape mutation that have a significant impact on viral fitness and disease progression. The molecular mechanisms by which HLAI micropolymorphisms can induce differential HIV-1 escape patterns within identical peptide epitopes remain unknown.
PubMed: 25808313
DOI: 10.1186/s12977-015-0149-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.18 Å)
Structure validation

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