4TYJ

Structural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase

Summary for 4TYJ

Entry DOI	10.2210/pdb4tyj/pdb
Related	4TYE 4TYG 4TYI
Descriptor	Fibroblast growth factor receptor 4, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	fibroblast growth factor receptor, kinase, transferase, dovitinib, ponatinb, proteros biostructures gmbh
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Cytoplasm : P22455
Total number of polymer chains	1
Total formula weight	35473.63
Authors	Lesca, E.,Lammens, A.,Huber, R.,Augustin, M. (deposition date: 2014-07-08, release date: 2014-09-24, Last modification date: 2014-12-10)
Primary citation	Lesca, E.,Lammens, A.,Huber, R.,Augustin, M. Structural analysis of the human fibroblast growth factor receptor 4 kinase. J.Mol.Biol., 426:3744-3756, 2014 Cited by PubMed: 25219510 DOI: 10.1016/j.jmb.2014.09.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation