4TWP
The crystal structure of human abl1 T315I gatekeeper mutant kinase domain in complex with axitinib
Summary for 4TWP
| Entry DOI | 10.2210/pdb4twp/pdb |
| Descriptor | Tyrosine-protein kinase ABL1, AXITINIB, NICKEL (II) ION, ... (5 entities in total) |
| Functional Keywords | gatekeeper mutant kinase domain dfgin, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519 |
| Total number of polymer chains | 2 |
| Total formula weight | 63910.77 |
| Authors | Johnson, E.,McTigue, M.,Cronin, C.N. (deposition date: 2014-07-01, release date: 2015-02-11, Last modification date: 2023-12-27) |
| Primary citation | Pemovska, T.,Johnson, E.,Kontro, M.,Repasky, G.A.,Chen, J.,Wells, P.,Cronin, C.N.,McTigue, M.,Kallioniemi, O.,Porkka, K.,Murray, B.W.,Wennerberg, K. Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation. Nature, 519:102-105, 2015 Cited by PubMed: 25686603DOI: 10.1038/nature14119 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report
